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Horm Res Paediatr

Summary: Vitamin B12 supplements can be taken at any time of day, as absorption mechanisms function consistently throughout the 24-hour cycle, with consistency being more important than specific timing

This creates a fundamentally different situation than traditional drug use

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However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives