Targeting mitochondrial metabolism and bioenergetics AMPK alpha 1 AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine kinase complex present in all animals, serving as a crucial metabolic sensor to maintain cellular energy balance during stress
No aversion was induced by mutants in earlier or later steps of ECA synthesis, suggesting that accumulation of an inner membrane intermediate, rather than the loss of ECA, drives C
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This oxidative burst serves dual roles: while moderate ROS levels activate antiviral signaling, excessive ROS production triggers mitochondrial permeability transition, mtDNA release, and cell death (Kayesh et al., 2025)
doi: 10.1016/j.semarthrit.2014.05.008 91 SchultheissJPDBrandECLamersEvan den BergWCMvan SchaikFDMOldenburgBet al
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