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A catch-22: interleukin-22 and cancer

Deletion of the key catalytic enzyme methylthioadenosine phosphorylase (MTAP) gene is associated with the sensitivity of GSK3368715, 331 and a current phase II clinical study of GSK3368715 in breast cancer has been enrolled (NCT04676516) (Table 1)

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Methaemoglobinaemia: In the erythrocyte, the active metabolite interacts with molecular oxygen (O 2 ), which then oxidises haemoglobin (Fe 2+ ) to methaemoglobin (Fe 3+ ) and also oxidises the active metabolite itself (Fig