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10.1186/s12967-021-02745-1 28 LiY.YangL.WangL.ZhangM.HuangZ.DengQ.et al (2017)

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A Crowded Pipeline Means Strategic Differentiation Is Critical With over 100 assets in clinical development, ranging from multi-agonists like retatrutide (with potential for ~25% weight loss) to oral small molecules like orforglipron , the battle for clinical and commercial leadership will be intense [3]

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Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)

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It is best viewed as a support tool rather than a primary fat loss driver

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NCT02207374

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