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Proteins, including tight junction proteins such as the claudins and occludins control paracellular permeability, defined as the conductance of water and small solutes through the spaces between adjacent epithelial cells [33, 34]

NAD+ and Mitochondrial Function in Longevity Research NAD+ (nicotinamide adenine dinucleotide) is a coenzyme with a central role in mitochondrial energy metabolism and DNA repair signaling

The impairment and uncoupling of ETC leads to the excessive generation of ROS, which further trigger a series of cellular injuries

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