Sources: Neelakantan et al., Biochem Pharmacol 2018 | Dimet-Wiley et al., Sci Rep 2024 Security Profile & Chemical Identity Molecular specifications and preclinical safety data 5-Amino-1MQ Chemical Identity A small molecule derived from quinolinium salts, developed at the University of Texas (2017) 5-Amino-1MQ Tolerance & Status Safety data from preclinical studies (DIO mouse model) Published Preclinical Data 3 key studies published in Biochemical Pharmacology and Scientific Reports 35% Reduction of white adipose tissue in 11 days (20 mg/kg, 3 times/day) Physical Effects (11 days) + 40 % Improvement of grip strength in aged mice (22-24 months) Strength & Performance (aged mice) microbiome The combination of 5-Amino-1MQ + caloric restriction establishes a distinct gut microbial profile Protocol & Results Important Notice Search Only Not intended for human consumption
doi: 10.1016/j.isci.2023.106935
stronger evidence comes from subsequent studies like the 2016 Lee et al
Am J Respir Crit Care Med 182(11):13441351 Dorecka M, Siemianowicz K, Francuz T, Garczorz W, Chyra A, Klych A et al (2013) Exendin-4 and GLP-1 decreases induced expression of ICAM-1, VCAM-1 and RAGE in human retinal pigment epithelial cells
Leading compounds including brensocatib, BI 1291583, and HSK31858 have demonstrated substantial clinical efficacy
BPC 157 Based on 1 Customer Validation BPC 157 is the 15-amino acide fragment of gastric peptide BPC
