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First, although all four tirzepatide RCTs were either phase 2 or 3 trials, they were not designed as CVOTs and were evidently underpowered to evaluate cardiovascular efficacy as indicated by the small sample sizes and short follow-up periods

PMID: 8426207

Neurosci Biobehav Rev 2015

Some people may be allergic to certain compounds in cyanocobalamin, making them unsuited for the injections.

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