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The RR for the proportion of participants experiencing at least one SAE between semaglutide and placebo arms was 0.40 (95% CI 0.06 to 1.72

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It gives Novo Nordisk an opportunity to remain competitive on efficacy while it continues developing next-generation therapies. Other drugs have already shown greater efficacy in prior studies, and the broader GLP-1 space is likely to see much more significant change as new molecules enter the market. Balazs called the higher dosage a major jump, noting that the incidences of stomach- and skin-related side effects at this higher dose are meaningful. This approval is for obesity management, not diabetes treatment, the expert emphasized

Supply shortages: Certain semaglutide formulations have experienced intermittent shortages due to high demand, leading to unintentional discontinuation

A 2021 preclinical study in rats showed that targeted lesioning of the area postrema abolished GLP-1 agonist-induced conditioned taste aversion, a proxy for nausea, while preserving the drug's appetite-suppressing effects [7]