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No significant inter-group difference was observed with regard to the primary outcome (physical function on the Short-Form 36 subscale at 6 months) [168]
Compared with other neuropsychiatric illnesses, most studies on the effects of GLP-1RAs in psychotic disorders seem to have focused so far on their potential use to counteract the cardiometabolic side effects due to antipsychotic medications
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Two-way ANOVA was used to analyze differences with two independent factors
The double-blind, randomised, placebo-controlled STRIDE trial achieved its primary endpoint, with semaglutide 1.0 mg demonstrating a superior and clinically meaningful improvement of 13% in maximum walking distance and a mean treatment difference of 39.9 m on a steep incline, compared to placebo at week 52
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