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GLP-1 and GIP receptors affect appetite, insulin sensitivity, and satiety

These findings suggest that simultaneous engagement of GIP, GCG, and GLP-1 receptors in humans may offer a significant therapeutic advantage in the management of T2DM [104]

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This energy boost supports increased physical activity, creating a positive cycle of improved fitness and continued weight loss

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These typically occur in 20-40% of patients and include: Nausea (most common, especially during dose increases) Vomiting Diarrhea Stomach pain Decreased appetite Constipation These side effects usually improve over time as your body adjusts to the medication