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Furgiuele S, Descamps G, Cascarano L,Boucq A, Dubois C,Journe F,Saussez S

For example, some studies have found that the secondary mutations of D1228N/V and Y1230C in the MET kinase domain are the main mechanisms for acquired resistance to crizotinib in METex14 patients receiving c-MET inhibitor treatment [149, 150]

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Mass Spectrometry (MS): This test verifies the precise molecular weight and amino acid sequence of both individual components, guaranteeing that no cross-contamination or structural degradation has occurred

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