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GLP-1 receptor agonists are a class of medications originally developed for type 2 diabetes management and now some are also licensed for weight management

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Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways

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