If you're not dosing fasted in the morning, you're leaving efficacy on the table
Clinical Considerations Disease-Associated Maternal and/or Embryo/Fetal Risk Deficiency of essential vitamins has been associated with adverse pregnancy and fetal outcomes, such as maternal folic acid deficiency and an increased risk of neural tube defects
There are exceptions to this but in general it is left to Pharmaceutical companies to develop medicines that can be used to treat diseases like Pernicious Anaemia
Stier H., Vos E., Kenley D
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Older adults : Aging can affect the stomachs ability to produce stomach acid, which is necessary for B12 absorption