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Nature Reviews Gastroenterology & Hepatology , 16(1), 3556

This effect begins with the very first dose, though it strengthens over subsequent weeks as drug levels accumulate

(2005, January)

Reducing the medication over a period of about two months gives your body time to adapt to the increase in ghrelin levels gradually, avoiding a sudden shock to your system

Safety and Side Effects Observed So Far Side effects reported in retatrutide trials were generally consistent with other incretin-based therapies, most commonly involving gastrointestinal symptoms

Researchers in clinical trials advised participants to limit alcohol intake