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Special Precautions & Warnings: For Pregnancy and breast-feeding: Pregnant and lactating mothers should not take any single supplement in higher-than-normal doses unless recommended by a health-care provider for a special condition

Essential for maintaining normal mitochondrial function, mitochondrial biosynthesis is regulated by key factors such as Peroxisome receptor gamma coactivator 1-alpha (PGC-1) and silent information regulator factor 2-related enzyme1 (SirT1)

Patients should be informed of the pros and cons of oral versus parenteral therapy, and regardless of the form of treatment, those with pernicious anemia or malabsorption should be reminded of the need for lifelong replacement