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At 24 weeks, participants receiving the lowest dose (1 mg) lost 7.2% of body weight, while those on 4 mg lost 12.9% of body weight on average

Moreover, the decreased thrombomodulin-dependent activation of protein C observed in hyperhomocysteinemic primates suggests that a moderate increase in circulating homocysteine alters endothelial antithrombotic properties (Lentz et al, 1996)

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