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The next step in the pathway is the conversion of 3-hydroxyanthranilic acid to quinolinic acid catalyzed by the enzyme 3-hydroxyanthranilate 3,4-dioxygenase which is encoded by the HAAO gene

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Epigenetic mechanisms include DNA methylation, histone modification, and the presence of small non-coding ribonucleic acid (RNA) molecules such as micro-RNA (miRNA) that regulate the post-transcriptional expression of target genes in the oncogenic process [29]

This approach is more precise than relying on the report odds ratio, particularly in situations with limited cases [30]

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