Addgene), 5.8 g pMD2.G (#12259
Furthermore, it was believed that synthetic derivatives of ternatin have shown cytotoxic effects directed only toward cancer cells, moreover, it was determined that it has even higher activity than natural ternatin (Carelli et al., 2015)
Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]
Methanol, chloroform, sodium bicarbonate, and sodium hydroxide were obtained from MERK (Damstadt, Germany)
Focal Adhesion Kinase (FAK) and paxillin are crucial proteins involved in focal adhesions, which are dynamic structures that mediate cell attachment to the extracellular matrix and play a pivotal role in cell spreading and migration
Purpose: The aim of this study is to investigate the potential protective effects of roflumilast against MTX-induced liver toxicity in Wistar rats
