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Close monitoring is necessary if these medications are used together. 7

For example, liraglutide was launched in 2010, dulaglutide in 2014, and tirzepatide in 2022 (Figure 2a)

It wasn't until recently, in 2021, that this drug got the green light to be used specifically for obesity, under the name Wegovy

Note: Phase 2 trials also tested a 1 mg starting dose, which showed modest results

The bulk discount has shrunk since we last checked in, but the subscription discount has increased from 15% to 20%

Larger, more complex peptides tend to carry richer impurity profiles, so scrutinize the single largest impurity, total related substances, and the test method not just the headline purity percentage