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Contraindications include epilepsy, severe renal impairment, and known hypersensitivity to the compound

Studies have shown that it is relatively safe with minor side effects, which may include temporary redness, itching or headache at the injection site

optional cycling with 6-week breaks between courses

Herdy et al., 2022), and N6-methyladenosine (m6A) methyltransferase METTL3 regulation of the NEAT1/miR-377-3p/Nampt in mouse astrocytes in cerebral ischemia (Hu et al., 2024)

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Simultaneously, decarboxylated S-adenosylmethionine (dcSAM), derived from Met metabolism, serves as the source of aminopropyl groups for the synthesis of spermidine and spermine (Wallace et al., 2003)