The Hypothalamus: This area of the brain is the master control centre for appetite and energy balance
Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, currently under clinical development for obesity and type 2 diabetes
Tirzepatide has a plasma half-life of approximately 5 days (120 hours), supporting once-weekly subcutaneous dosing
For some people, that means Greek yogurt, eggs, chicken, soup, oatmeal, berries, and cucumbers
Unlike dual-agonist compounds, Retatrutide also activates the glucagon receptor, giving it a unique pharmacological profile for metabolic research
Key Differences Between Tirzepatide and GLP-1 Medications Single vs Dual Pathway GLP-1 medications activate one receptor