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Indeed, small human studies found that eating foods like pineapples, kiwis, oranges, or bananas, all containing relevant levels of melatonin, increased serum melatonin by melatonin 23-fold shortly after consumption (Pereira et al., 2022

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In the HD model, reduced expression and deacetylase activity of SIRT3, which in turn prevents the deacetylation of LKB1 and SOD2, leading to a decrease in the level of NAD + , defects in mitochondrial biogenesis and accumulation of ROS