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Research demonstrates that daily dosing at 500-1000mg levels produces measurable increases in cellular glutathione concentrations across multiple tissue types [1]

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This 2011 meta analysis of 86 different studies on glutamine and gut permeability, found: A significant body of evidence indicates that glutamine preserves the gut barrier function." And just as importantly the researchers found Glutamine is considered the most important nutrient for healing of leaky gut syndrome because it is the preferred fuel for enterocytes and colonocytes By contrast, Glutathiones main function is to kill free radicals and inflammatory compounds called Reactive Oxygen Species

1) Harvest cells from a 50 mL culture by centrifugation at 4C (e.g., 5,000 rpm for 15 minutes)

Genetic variants in antioxidant enzyme genes (glutathione synthase, GPX, SOD) influence cellular glutathione production capacity

When glutamine levels are low, glutathione levels are also low