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Novel double-layered PLGA microparticles-dissolving microneedle (MPs-DMN) system for peptide drugs sustained release by transdermal delivery
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The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]
3.3.2 Anti-cell death agents In addition to fueling a damaging inflammatory cycle, unchecked oxidative stress directly triggers multiple cell death pathways
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