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Retrieved, from (August 9, 2024)
& Ingwersen, S
Background Several medications reduce antipsychotic weight gain, including metformin, topiramate, and the partial opioid antagonist samidorphan (available as an olanzapine combination pill, Lybalvi)
The most common early side effects include nausea (affecting 2040% of patients), mild abdominal discomfort, and changes in bowel habits
JACC Basic Transl
The weight loss took place over 80 weeks in a late-stage trial, with almost two-thirds of participants who took the maximum dose of the drug achieving a BMI less than 30, which put them out of the obese range
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