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Aging Cell (2011) 10(6):9961010.10.1111/j.1474-9726.2011.00740.x 197 IranmaneshALizarraldeGVeldhuisJD

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580,581 Clinical progression of AD is defined first by massive synapse loss and subsequently by neuronal death, which ultimately results in profound brain atrophy and is clinically manifested by severe dementia

This is not an aesthetic-dose phenomenon, but it explains why benzyl alcohol products are contraindicated in neonates and used cautiously in young children