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Phentermine: Not approved for long-term use due to potential for abuse and side effects

The liver benefits are maintenance-oriented at this stage: preventing re-elevation rather than producing further improvement

The right exercise approach protects muscle mass, supports bone health, and improves metabolic markers that medication alone cannot fully address

Future research directions and challenges Development of new derivatives Local delivery system: study the complex of IGF 1 LR3 1mg and hydrogel or nanoparticles to achieve targeted release and reduce systemic side effects

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PMID: 7572711