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Lawsuits point to evidence that drugmakers were aware of more long-term risks than they disclosed, continuing to market GLP-1 drugs as safe for widespread use

Because an oral 15-PGDH inhibitor has already passed Phase 1 safety testing in humans for age-related #muscle weakness, the authors are hopeful that clinical trials in joint disease will follow, potentially paving the way for #nonsurgical, cartilage-regenerating therapies that could delay or replace knee and hip replacements

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Figure 1 illustrates the deduplication process

If they start using semaglutide, their doctor may adjust their insulin dose