Altered Intercellular Communication and ImmuneEndothelial Cross-Talk Aging is also characterized by altered intercellular communication, particularly between immune cells, vascular tissue, and metabolic organs
483 These studies suggest that the well-tolerated and inexpensive antidiabetic drug metformin impairs the promotion of PDAC either through direct inhibitory effects on pancreatic cells harboring an activating Kras mutation and/or indirectly through effects on the tumor microenvironment or extrapancreatic sites that sustain a chronic inflammatory state and amplify the progression of PDAC
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