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They were subsequently able to investigate causality more thoroughly using rat experiments

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8.5 Geriatric Use In clinical studies of 24 weeks or greater duration, 415 patients were over 65 years of age and no patients were greater than 75 years of age

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Renal Fail 38(7):11071114 Trayhurn P, Beattie JH (2001) Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ