As a consequence, a loss of lipoic acid-dependent enzymatic activity caused by defects in endogenous lipoic acid synthesis (see Deficiency) cannot be rescued by the provision of exogenous lipoic acid (5)
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Martin LW, Swisher SG , Hofstetter W, Correa AM, Mehran RJ, Rice DC, Vaporciyan AA, Walsh GL, Roth JA
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Buffering: To mitigate irritation when using both at night, apply moisturizer before tretinoin to act as a buffer