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They are often prescribed for individuals who are unable to absorb the vitamin effectively through oral supplements

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People with serious kidney problems should use B12 supplements with caution

In contrast, when bound to transcobalamin II, the half-life is significantly shorter, approximately 1.5 hours, although the final plasma curves for both forms yield similar half-life values of around 9.3 to 9.8 days due to the rapid reappearance of the radiocobalt label bound to transcobalamin I