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Leukocyte and neutrophil mean cell counts remained within normal range between screening, baseline and throughout the pivotal Phase 3 (leukocytes: normal range 4.010.0 109/L mean count at Day 182: 6.6 109/L with garadacimab [n = 39], 6.2 109/L with placebo [n = 24], neutrophils: normal range 2.07.0 109/L, mean count at Day 182: 4.0 109/L with garadacimab, 3.9 109/L with placebo) and OLE studies (At Month 12 [n = 140]: leukocytes: 6.4 109/L

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Currently, there is limited evidence on the safety and efficacy of intermittent dosing strategies, and the consensus among obesity specialists is that this approach is not generally advised except in specific clinical scenarios under close supervision

Critics argue that the definition of UPF needs refinement, and more clinical studies are required

With its ability to protect and detoxify, it also provides crucial immune system support

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