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During periods of high metabolic demand, intense physical exertion, or cellular stress, the mitochondria can become overwhelmed by partially processed metabolic byproducts, specifically excess acetyl-CoA

[58] It lacks rigorous clinical trials for this indication, but there is clinical experience with its off-label use as a prokinetic in several gastrointestinal motility disorders

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Temporary semaglutide discontinuation may be appropriate during acute illness, surgery, significant medication changes, or uncontrolled symptomatic hypotension