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Many products marketed as "GLP-1 supplements" claim to naturally increase GLP-1 activity or act as alternatives to prescription medications

Similar to other peptide-bound GLP-1R structures 13, 16 , exendin-4 and oxyntomodulin adopted a continuous alpha helix, with their C-terminus bound within the ECD and their N-terminus bound deep within the TMD forming extensive interactions with residues within TM1, TM2, TM3 TM5, TM6, TM7 and ECL2 (Figures 1-2, Supplemental Figure 4)

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doi:10.3390/ijms18102147 [15] Obrenovich MEM

As their use has expanded dramatically in recent years, questions about long-term safety, including potential cancer risk, have become increasingly important for both patients and clinicians

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