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The consequence is critical: there is less muscle available to absorb glucose and we start to become relatively insulin resistant

Smaller meals are often better tolerated

The half-life of semaglutide is approximately seven days, meaning the medication remains active in your system long enough to deliver consistent therapeutic effects before the next weekly dose

These renal benefits independently contribute to cardiovascular risk reduction, though SGLT2 inhibitors remain foundational therapy for heart failure and CKD when appropriate