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Insulin resistance exacerbated pathological PD features which contributed to disease progression via increases in -synuclein accumulation in dopaminergic neurons, oxidative stress, and mitochondrial dysfunction

This results in decreased autophagy and increased apoptosis, contributing to Schwann cell dysfunction

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Sci Rep 8:1603 Sailasuta N, Ananworanich J, Lerdlum S, Sithinamsuwan P, Fletcher JL, Tipsuk S, Pothisri M, Jadwattanakul T, Jirajariyavej S, Chalermchai T, Catella S, Busovaca E, Desai A, Paul R, Valcour V, Group SS (2016) Neuronal-glia markers by magnetic resonance spectroscopy in HIV before and after combination Antiretroviral Therapy

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B12 anaemia means you either have fewer red blood cells, or there is a lower amount than normal of haemoglobin in each of your red blood cells