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Metabolic Pathways and Glucose/Fat Handling IGF-1 LR3 is also applied in metabolic research examining glucose and lipid regulation: Receptor Interactions: The peptide has been reported to engage both the IGF-1 receptor (IGF-1R) and, to a lesser extent, the insulin receptor in experimental systems, providing a means to investigate converging signaling cascades in muscle, liver, and nerve tissues

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