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391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under the brand name Ozempic) and chronic weight management (Wegovy)
Finding the right person was difficult because many at the time, like Fraser, were highly sceptical about the clinical potential of RIA
Biggest unknown is whether Doustdar (and his management team) will be able to turn the ship, since I expect that their results (whether positive or negative) will have a major impact
Transparent dialogue with doctors and insurers is key to managing prescriptions and optimizing access to affordable care
