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Topical GHK-Cu has minimal systemic absorption

The Plant Cell 34, 30473065

While they found better skin outcomes in participants who used hydroquinone cream (a common melasma intervention), they also concluded that topical silymarin was also effective and produced fewer side effects.28 Wrinkles A lack of skin moisture is one of the factors behind fine lines and wrinkles.29 According to a 2012 study published in the African Journal of Biotechnology , milk thistle extract, emulsified into a topical cream, may help combat wrinkle formation by boosting moisture retention and preventing transepidermal water loss.30 An important caveat to consider is that all of our top recommended milk thistles are oral supplements, and research on oral milk thistle for the above purposes is somewhat lacking

(PubMed) Clark LC, Combs GF, Jr., Turnbull BW, et al

It lowers sperm count significantly

The endothelial cells lining our blood vessels are responsible for controlling vascular tone and blood flow