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Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

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Nuclear hormone receptors are able to directly regulate transcription upon ligand binding

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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

However, the additional GIP pathway means that stopping tirzepatide involves a more complex physiological adjustment than stopping semaglutide