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Therefore, our cohort is homogeneous and the diagnostic strategy used to build this cohort (systematical histologic review, immunohistochemistry, and molecular analysis) is relevant

Key actions: Regulates melanin production Helps fade dark spots Improves skin clarity Safe for long-term use under guidance 3

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In addition, all operations were approved by the Animal Research Ethics Committees (AREC) of the University of Sumatera Utaras Faculty of Mathematics and Natural Science, Biological Department, with the approval number 0423/KEPH-FMIPA/2021, 14 July 2021

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