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In the p53 TAD apo state, most residues showed low values ( 0.2 was observed for residues corresponding to TAD2 and the C-terminus (Figure

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Transcriptomic and functional analysis demonstrated metformin-mediated alterations to energy metabolism, mitochondrial function, cell cycle distribution and progression, cell death and antioxidant levels in colorectal cancer cells

You're not creating a dangerous interaction, but you're reducing glutathione bioavailability by 3040%

Arrows indicate stimulation (green), inhibition (blue), and the resulting cardiovascular effects (red)