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doi: 10.1038/s41586-019-1263-7 9 BuckleyCDPillingDLordJMAkbarANScheel-ToellnerDSalmonM

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In ovarian cancer cell lines SKOV-3 and OVCAR-3, Ex-4 induces apoptosis by modulating NF-B downstream targets, including matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1(ICAM-1), BAX, Bcl-2, and cyclin D [68]