It does not disrupt the interaction between dimers in the glutaminase tetramer but binds to the hydrophobic pocket between the monomer-monomer interface of the GAC, located at the junction where the N-terminal and C-terminal of the enzyme meet the catalytic domain, thereby preventing the GAC from activating conformational changes (Wilson et al., 2013
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Styles 1993a
They both require pyridoxal-5-phosphate, the active form of vitamin B6, as a cofactor for their enzymatic activity [26, 27, 28]
By 37 weeks, a baby's lungs are usually mature, so antenatal steroids are not routinely given (WHO) The injection is used mainly for preterm (before 37 weeks) births