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Biochemistry 48(11):24592467 Suzuki H, Kajimoto Y, Kumagai H (2002) Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial gamma-glutamyltranspeptidase

The induction and intensification of cell death, along with barriers to macrophage clearance and absorption of dead cells, increase the exposure of intracellular contents to the immune system, triggering an immune response

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Treatment with FOXO4-DRI following chemotherapy exposure potently counteracts these effects, normalizing body weight and reducing plasma AST to near-baseline levels

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