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As of April 2025, retatrutide has not received MHRA marketing authorisation and is not available on the NHS

Some start on semaglutide and transition to tirzepatide as their treatment progresses and their physician adjusts the plan based on real-world results

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The rare scenario where faster escalation might make sense is someone who has been on a comparable dose of another incretin therapy and already has established GI tolerance to receptor agonists

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July 2023: ASHP, the largest association of pharmacy professionals in the U.S., advised that Novo Nordisk was running short of Ozempic and Wegovy, another semaglutide, because of increased demand