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And as youve probably guessed, it all comes down to those pesky/ downright obnoxious hormones

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[29] Those two novel peptides were later isolated, identified, and investigated by other researchers, and are now known as glucagon-like peptide-1 and glucagon-like peptide-2

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Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data