It works by mimicking an incretin hormone that enhances insulin release, suppresses glucagon secretion, and slows gastric emptying, which in turn lowers blood sugar levels, as well as promotes weight loss
6 This deficiency is particularly concerning for GLP-1 users who may experience gastrointestinal side effects like diarrhoea (5-36% of semaglutide users) and constipation (5-37% of semaglutide users)
Most side effects ease as your body adapts
They create multiple entry points based on the size and target area
Drug interactions and side effects of Semaglutide In studying the effects of semaglutide treatment on the pharmacokinetics metformin, warfarin, atorvastatin and digoxin, it was found that this GLP-1 analog did not affect such properties to a clinically relevant degree (Hausner et al., 2017)
The rush to capitalise on GLP-1 drugs success is having wider implications for the pharmaceutical industry: Manufacturing capacity is being diverted from other therapeutic areas to meet GLP-1 demand