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( D ) Representative Western blots demonstrating that ALOX15 KD also decreases GPX4 protein expression ( n = 4)

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Nevertheless, PS translocation to the outer leaflet of the phospholipid bilayer, a hallmark of eryptosis, can frequently occur without caspase-3 recruitment, primarily in response to Ca 2+ overload [84]

These effects were associated with increased nuclear factor erythroid 2-related factor 2 (Nrf2) gene expression, suggesting involvement of both antioxidant and anti-inflammatory mechanisms (Jafari et al., 2022)